Top 10 Best Ergonomic Wireless Mouse In 2022

The keyboard and mouse are the most direct and hands-on input aspects of your computer. Even though the mouse is a basic pointing device, it can have several unique designs, features, and comfort levels. It is necessary to understand the different types and designs when shopping.

Why do you need an ergonomic mouse? Most of us hardly give a second thought to the mouse we use, but it is crucial for our wrist, arm, and hand health. Ignoring this can have long-term and serious repercussions on your health.

List of The Best Ergonomic Wireless Mouse In 2022

1. Logitech Wireless Trackball M570 Review

Logitech Wireless Trackball M570 Review
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Even from the most comfortable seat or coffee table, there is no ultimate position for the best cursor control. However, with this hand-friendly wireless trackball mouse, you can work and play anywhere you want. Just roll and click and forget about cramped hands.

It offers smooth, precise laser-sensor control even on your bed, features powerful 30 ft. wireless range and can operate for 18 months on a single AA battery. It offers enhanced comfort and is safe for your hands, even if you use it for extended periods.

2. Logitech MX ERGO Advanced Wireless Trackball Review

Logitech MX ERGO Advanced Wireless Trackball Review
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This trackball features a unique adjustable hinge that allows you to choose the best angle between 0 to 20 degrees. This gives a more natural position for the hand and comforts to each hand size and shape. Compared to the regular mouse, this one gives 20 percent less muscular strain.

It provides advanced optical tracking accuracy and can easily switch and navigate between two computers. Make your workflow convenient and comfortable. It has soft rubber on top to ensure a comfortable grip even for long hours use. It can operate up to 32 feet in wireless range, and the battery can last up to 4 months when fully charged.

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3. Evoluent VerticalMouse Review

Evoluent VerticalMouse Review
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It is time you avoid twisting your forearm and work in complete comfort. This upright shaped mouse gives your arm a neutral position for the best for your health. This mouse offers excellent comfort and relieves wrist pain for those who work long hours on their computers.

It has easy-to-reach programmable buttons and does not require finger contortions to operate the buttons. It features an improved thumb rest and a new bottom thumb button for extended functionality when used with the provided driver.

Your last finger is protected from rubbing the desk by an extra wide rubber lip. It has pointer speed control and indicator for convenience; you do not even have to remove your fingers from the grip to adjust the speed.


4. Microsoft Natural Wireless Laser Mouse 6000 Review

Microsoft Natural Wireless Laser Mouse 6000 Review
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The mouse is so comfortable you will wonder how you survived all these years without it. It offers unmatched ergonomics, style, accuracy, and other advanced features.

The mouse design conforms to your hand position naturally for relaxed working. It features a tilted, elevated hand position that reduces pressure on the carpal tunnel and wrist for the most comfortable use and excellent performance.

It offers smooth 4-way scrolling and smooth tracking. All these ensure your hand gets the least strain as you work and the highest responsiveness for increased productivity. Its scroll wheel tilts from side to side and reacts to your speed for smooth and accurate maneuverability.

5. Swiftpoint GT Wireless Ergonomic Mobile Mouse Review

Swiftpoint GT Wireless Ergonomic Mobile Mouse Review
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This ultra-portable wireless mouse offers excellent ergonomics to help you get a lot of work done in less time. It combines natural touch gestures with the precision and convenience of a traditional mouse. This bridges the gap between touch and non-touch modes of operating your tablet, laptop, and desktop.

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The Swiftpoint GT is unlike any other mouse since it enables a full range of touch gestures with a natural finger and wrist action. No need to reach for the screen and you do not even need a touchscreen to experience the wonder of working with this mouse.

It has a unique, truly natural touch implementation that makes the mouse easier to use compared to the computer mouse with touch sensors on the mouse and will accelerate your work and productivity while reducing fatigue by reducing the motions of your head, eyes, and hand.

It offers a comfortable pen-like grip for the right-handed user. You can also change the button assignments to suit your unique needs and enhance your comfort.

6. Logitech MX Master Wireless Mouse Review

Logitech MX Master Wireless Mouse Review
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Both users and masters of crafts will have the ultimate experience using this Logitech’s flagship mouse. It gets work done faster and more efficiently. Its advanced features and stunning design make it the best mouse for PC and Mac for the ultimate comfort, precision, control, and customization.

It has a hand-sculpted shape for excellent comfort. It is contoured to support your hand and wrist in a natural position. Also, it has well-positioned wheels and buttons enabling fine-motion control and comfortable fluid experience.

The mouse mold is made from an originally hand sculpted design. The advanced features will require driver installation; the downloads are available from the Logitech website. The battery life varies according to the user and computing conditions.

7. Evoluent VerticalMouse 4 Right Wireless Review

Evoluent VerticalMouse 4 Right Wireless Review
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This mouse has a thoughtfully designed shape for the ultimate uncompromised comfort and ease of use. It has easy-to-reach programmable buttons that ensure no finger contortions when using it. You can adjust the optical sensor and pointer speed at the side for convenient adjustment without having to release your grip.

To make it even more comfortable, the mouse has an improved thumb rest reshaped to provide more comfort. The top mounted LED indicators to show the mouse speed so you can see and change if necessary. When used with the included driver you can have extended functionality including the two thumb controls.

It has a tiny 2.4GHz receiver that will not easily be knocked off the side of your notebook computer. It has an extra wide lip along its bottom edge to prevent your last finger from rubbing on the desk. The powerful and intuitive driver offers excellent and extended functionality for the six buttons.

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8. ELECOM M-HT1DRBK Wireless Trackball Mouse Review

ELECOM M-HT1DRBK Wireless Trackball Mouse Review
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Experience effortless gliding and smooth, precise operation due to the synthetic ruby bearings. Its large bearings require less maintenance. It features eight buttons and a tilt wheel to support your gaming needs and give you limitless click combinations.

The pointer sped can easily swap between three DPI on the fly the wide scrolling wheel provides adequate finger contact for fast, precise operation. With the Elecom Mouse Assistant, you can assign up to 10 commonly used functions to the buttons to make your work easier.

Its fast forward and back navigation button at the thumb makes it easy and efficient to change pages or websites. The trackball is removable to allow cleaning trapped dirt or grime. This makes it easy to clean and maintain the ball and cradle.

9. KINESIS PD7DXT-WR DXT Wireless Ergonomic Mouse 2 Review

KINESIS PD7DXT-WR DXT Wireless Ergonomic Mouse 2 Review
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The mouse requires no cable, and its wireless Micro USB dongle is compatible with PC, Mac & Linux. It works up to 30 feet away and is suitable for both left and right-hand users. It instantly switches between right, left making it the most efficient ambidextrous mouse, fully charges in 90 minutes, and works for up to 2 weeks on normal usage.

The mouse has a relaxing ergonomic design for natural wrist and hand position. The Zinc base improves stability and accuracy. Experience precise grip for accurate navigation. Its compact design fits most hand sizes.

10. LOGITECH, INC. Optical TrackMan Cordless Mouse Review

LOGITECH, INC. Optical TrackMan Cordless Mouse Review
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Logitech Cordless TrackMan mouse is an excellent programmable mouse for comfort and advanced functionality. Its six programmable buttons can be customized as desired for frequently sued functions to make your work faster and easier.

What to look for


Size matters when it comes to the mouse. Those that are too large for your hands or too small will not be comfortable. They may cause cramping or stretching of your tendons unnaturally. The mouse may have advanced features, but if it does not fit your hands comfortably, then it is not a good model. Before you consider any other feature, look for a mouse that fits your hands well. Anything that is too big or tiny will not serve you well.


This depends on the person’s taste. Some will prefer heavier mouse while others like it light and fast for little resistance. You will need more effort to move a heavier mouse compared to the lighter one, even though you will not realize it in the beginning.
The type of cord will play a role in the weight and movement of the mouse. The other factor is the battery that may make it heavier.

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A hand at rest is not flat but has a contour, an arch. The crucial aspect when buying a mouse is that it should reproduce the arch. Some designs have a vertical mouse to allow for a natural hand position. Go for the types that will create this contour if you want your hand to remain healthy for longer.

Thumb rest

Some mouse are designed with plateaus that keeps the thumb off its traveling surface. This reduces surface friction and drags on the thumb. Some have a resting spot to rest the fingers when not needed.

Ease of movement

This is determined by weight to some extent. When you use more pressure to push the mouse, you add strain on the hand, wrist, and arm. The best mouse should present as little resistance as possible irrespective of its weight. The injuries of the hand and wrist usually build up slowly, so you will not realize you are harming it until it is too late.


The wheel and buttons should be designed to respond to the lightest of touch for your arm and writs health. Heavier resistance may feel good but continually harm your fingers and arm. Some mouse will let you toggle the click-vs.-smooth scroll action of the wheel.

Side grips

There are mouse designs that fit major hand shapes. Recent mutable designs have appeared offering a variety of grips that can be applied outside the mouse. They attach magnetically between the where the ring and pinky finger rests. This varies the size to fit various hand sizes and shapes.

Roughened grips

A slightly roughened texture is commonly added to side grips, especially on the ambidextrous mouse design. It helps you keep a firm hold on the mouse when it is on the move. A solid grip will let you relax your hands.

Button placement

A mouse does not need trendy button placement even if they appear inventive. If the buttons are placed at the wrong place, you will have tension building up slowly on the tendons and give you nerve strain. Every mouse button should be within easy reach of the fingers. The switches should be within comfortable reach and not too far.

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Ambidextrous mouse

Even lefties deserve ergonomic mouse. And since they account for about 10 percent of the population, it is a challenge designing mouse for that market. This challenge is solved by the ambidextrous mouse designs. They have a straight or hourglass design for a comfortable, secure grip. They have side buttons on the left and right. These mouse are designed to serve both lefties and right-handed persons.

Vertical mouse

A vertical mouse is a typical non-standard mouse design to solve the ergonomic challenge. It turns the hand at 90 degrees as if you are holding a cup. It then uses the wrist as a pivot point. This design prevents nerve impingement, tendon contortion, and unreasonable stretching.

DPI switching

The mouse ergonomics does not stop at the physical design. The accompanying software plays a significant role and adds great value. A mouse that allows you to switch to a higher DPI setting can help you manage items spread across a large area. You do not need to extend the arm too much or flex your wrist. Each swipe will give you more mileage with little effort.

Lift-distance wizard

This feature is beneficial if you regularly change the surface of the mouse. This wizard will ensure the mouse move properly by using an algorithm to determine optimal focusing distance between sensor and surface. Anything no matter how small that contributes to removing the tension from your hands is welcome.

Angle turning

This tilts the X and Y of the mouse by up to 30 degrees to the left or right to give you greater flexibility considering arm and wrist position.

Task automation through Macros

Macros can help you make lengthy, repetitive tasks seem simpler. When you cut down on these repetitive tasks, your hand will benefit. A mouse with even a basic macros editor with a few unassigned buttons will make your work easier and healthier on your hands.


This review of the best ergonomic wireless mouse is an eye opener into the world of mouse. It is also a great guide to help anyone get the right ergonomic mouse. No one mouse size and features fit everyone so get what suits you. Consider your preferences before setting out to buy a mouse.When you know what you want, you will have minimized the initial confusion by a large margin.Give your arms, hand, and wrist the best and most comfortable mouse to work with.

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